Effects of Cannabinoids 101

The effects of marijuana on the body is complex.  There are over 600 constituents of the plant, some of those constituents are known medically as cannabinoids.  We have two known receptors sites for cannabinoids; CB1 and CB2 receptor.  Cannabinoids bind to the receptor sites to produce the effects of marijuana. Cannabinoids works synergistically with one another.  For example, if you use solely the cannabinoid, CBD, the therapeutic effects are greatly reduced.  The majority of scientific research around cannabinoids are mostly on THC and CBD.  The following is a list of known cannabinoids and their therapeutic effects:

  • Cannabigerols (CBG); binds to CB2 receptors and studies show efficacy by reducing inflammation of the gut
  • Cannabichromenes (CBC); it is the second most abundant cannabinoid and shown to be an effective antibacterial agent
  • Cannabidiols (CBD); enhances analgesic effects of THC, it is neuroprotective and acts as an anticonvulsant , inhibits the the proliferation of cancer cells, it also has anti-anxiety and anti-psychotic effects.
  • Tetrahydrocannabinols (THC); binds to CB1 receptors and produces euphoria and potentiates other drugs, for example opiates
  • Cannabinol (CBN) and cannabinodiol (CBDL); potentiates the action of THC

Chronic use of marijuana reduces the amount of CB1 receptor sites available for THC to bind too.  Therefore the effects of THC are greatly reduced by chronic use.



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