A Taste of where Medical Marijuana Research is In Cancer

There are many studies done on medical marijuana, but how many of these findings are reputable?  The following is a brief synopsis. More research of this caliber is needed in order for marijuana to be accepted as a viable medicine within medical research/

Delta-9-THC, the main constituent found in marijuana is extremely hard to study in-vitro. Delta-9-THC is not water soluble but fat soluble.  It is extremely difficult for researchers to test delta-9-THC because in-vitro studies require extremely high concentrations of delta-9-concentrations which is difficult to achieve.  This causes researchers to study the effects of the synthetic version of delta-9-THC.  The synthetic version of delta-9-THC isn’t comparable to the natural version. The synthetic version of THC is really potent unlike the potency of the delta-9-THC.

Anticancer mechanisms of cannabinoids – there are CB1 & CB2 receptors sites found in cancerous cells but not necessary the tissue where the cancer cells proliferated from.  Findings showed that the deletion of the CB1 receptor in mice models stimulated growth of a tumor.  Findings also showed the the synthetic version of delta-9-THC can stimulate cell proliferation. CBD alone was found to have excellent anti-tumor effects in animal models but this finding was independent to CBD binding cannabis receptor. Though this looks promising, it is impossible to remove cannabis receptors in the body, therefor CBD would still bind to the receptor sites in the body which may not yield the same effect found in animal models.

Dilemma: delta-9-THC is studied most by its synthetic analogue. Since the synthetic analogue is more potent than natural delta-9-THC,   This causes a discrepancy whether natural delta-9-THC would yield the same effect of its synthetic analogue.

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